![]() ![]() Using paired samples from 1,351 participants taken ~5 years apart, we estimate the within-individual variability in LTL and provide a correction factor for this. Age, ethnicity, sex and white cell count explain ~5.5% of LTL variance. Higher white cell count is associated with shorter LTL, but proportions of white cell subtypes show weaker associations. Older paternal age at birth is associated with longer individual LTL. Compared to white Europeans, LTL is markedly longer in African and Chinese ancestries. We confirm that older age and male sex associate with shorter LTL, with women on average ~7 years younger in ‘biological age’ than men. Here we report the measurement and initial characterization of LTL in 474,074 participants in UK Biobank. Leukocyte telomere length (LTL) is a proposed marker of biological age. The relative risks were low at a population level, but our findings suggest that common factors acting on the myeloid and musculoskeleletal systems might influence later life musculoskeletal outcomes. ![]() ![]() In this, the largest study to date, longer LTL was associated with lower risk of incident knee or hip arthroplasty, but only weakly associated with lower risk of fracture. Associations with incident outcomes were not materially altered by adjustment for heel estimated bone mineral density, grip strength, gait speed, fat mass or blood biomarker measures. Longer LTL was weakly associated with reduced risk of any incident fracture in women with less evidence in men. In confounder-adjusted models, longer LTL was associated with reduced risk of incident knee arthroplasty in both men and women and hip arthroplasty in men but not women. During follow-up there were 5,619 fractures 5,285 hip and 4,261 knee arthroplasties. In further analyses we adjusted for either estimated bone mineral density from heel quantitative ultrasound, handgrip strength, gait speed, total fat mass (bioimpedance) or blood biomarkers, all measured at baseline (2006-2010). Covariates included age, white cell count, ethnicity, smoking, alcohol, physical activity and menopause (women). We used, in men and women separately, Cox proportional hazards models to calculate the hazard ratio for incident fracture (any, osteoporotic) or arthroplasty (hip or knee) over 1,186,410 person-years of follow-up. Leucocyte telomere length (LTL) was measured in baseline samples using a validated PCR method. We investigated independent associations between telomere length and risk of fracture and arthroplasty in UK Biobank participants. ![]()
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